Open AccessTSG-6 protein and its role during maturation of ovarian follicles
Author(s) -
P. Trzeciak,
Ł. Rąpała,
Rafał R. Starzyński,
Sebastian Dąbrowski,
A. M. Duszewska
Publication year - 2012
Publication title -
postępy higieny i medycyny doświadczalnej
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 34
eISSN - 1732-2693
pISSN - 0032-5449
DOI - 10.5604/17322693.1006408
Subject(s) - oocyte , ovulation , cumulus oophorus , ovarian follicle , microbiology and biotechnology , follicle , chemistry , medicine , andrology , endocrinology , biology , follicular phase , biochemistry , embryo , hormone
TSG-6 is an ~35 kDa glycoprotein belonging to the hyaluronan binding family. Its expression is induced as a result of an inflammatory condition and during ovulation. TSG-6 is a crucial protein engaged in extracellular matrix synthesis and organization of cumulus-oophorus-complexes (COCs) in preovulatory ovarian follicles. TSG-6 catalyzes cross-linking via heavy chains of trypsin α inhibitor and hyaluronan. This reaction is essential for proper cumulus cell expansion. This process is correlated with purchasing competence by the oocyte. Disorders of the synthesis of TSG-6 cause irregularities in expansion of cumulus cells during ovarian follicle maturation. Therefore, TSG-6 is a potential molecular marker of oocyte maturation.