Open AccessOxidative stress modulates the organization of erythrocyte membrane cytoskeleton
Author(s) -
Maria Olszewska,
Jerzy Wiatrow,
Joanna Bober,
E. Stachowska,
Edyta Gołembiewska,
Katarzyna Jakubowska,
Małgorzata Stańczyk-Dunaj,
Maria Pietrzak-Nowacka
Publication year - 2012
Publication title -
postępy higieny i medycyny doświadczalnej
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 34
eISSN - 1732-2693
pISSN - 0032-5449
DOI - 10.5604/17322693.1005677
Subject(s) - oxidative stress , pentose phosphate pathway , cytoskeleton , biochemistry , oxidative phosphorylation , chemistry , glutathione , antioxidant , hemoglobin , reactive oxygen species , microbiology and biotechnology , biophysics , biology , glycolysis , enzyme , cell
Apart from their main role in transporting oxygen and carbon dioxide, erythrocytes play also an important role in organism antioxidative defence. Direct exposure to reactive oxygen species (ROS) results in shortening of their half-life, even by 50%. The presence of glucose, being the substrate in pentose phosphate pathway (PPP) cycle, is one of the factors that can have influence on the level of oxidative stress. The activity of PPP increases during oxidative stress. Glucose guarantees normal PPP functioning with the production of reductive equivalents in the amounts necessary to reproduction of glutathione--nonenzymatic free radical scavenger. In available literature there are no reports regarding the changes in protein contents of erythrocyte cytoskeleton exposed to t-butyl hydroperoxide in relation to glucose presence in incubation medium.