Open AccessThe role of trophic factors and inflammatory processes in physical activity-induced neuroprotection in Parkinson’s disease
Author(s) -
Ewelina Pałasz,
Agnieszka Bąk,
Anna Gąsiorowska,
Grażyiewiadomska
Publication year - 2017
Publication title -
postępy higieny i medycyny doświadczalnej
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 34
eISSN - 1732-2693
pISSN - 0032-5449
DOI - 10.5604/01.3001.0010.3850
Subject(s) - neuroprotection , neurodegeneration , parkinson's disease , dopaminergic , neuroscience , disease , medicine , neurotrophin , neurotrophic factors , oxidative stress , dopamine , psychology , receptor
Glial cells and neurotrophins play an important role in maintaining homeostasis of the CNS. Disturbances of their function can lead to a number of nervous system diseases, including Parkinson's disease (PD). Current clinical studies provide evidence that moderate physical activity adapted to the health status of PD patients can support pharmacological treatment, slow down the onset of motor impairments, and extend the patients period of independence. Physical activity, by stimulating the production and release of endogenous trophic factors, prevents the neurodegeneration of dopaminergic neurons via inhibition of inflammatory processes and the reduction of oxidative stress. The aim of this study is to present the current state of knowledge for the anti-inflammatory and neuroprotective properties of physical activity as a supportive therapy in Parkinson's disease.