Open AccessCanonical analysis of concentrations of toxic metals in endometrium of women with gynecological disorders
Author(s) -
Katarzyna Tomczyk,
Paweł Rzymski,
Maciej Wilczak
Publication year - 2022
Publication title -
ginekologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 21
eISSN - 2543-6767
pISSN - 0017-0011
DOI - 10.5603/gp.a2022.0088
Subject(s) - endometrium , endometrial cancer , medicine , heavy metals , hyperplasia , physiology , endometrial hyperplasia , cancer , environmental chemistry , chemistry
Among the main adverse environmental factors, we usually distinguish the impact of heavy metals, especially Cd and Pb. Apart from the carcinogenic and toxic properties, their potential, stimulating estrogen receptors effect (metaloestrogens) is strongly emphasized; as well as participation in gene regulation mechanisms (epigenetic). The aim of this study is to examine if there is a special scheme of concentrations of heavy metals accumulated in the female endometrium in certain pathologies: endometrial hyperplasia, endometrial cancer, endometrial polyps and miscarriages. The control group consisted of patients with abnormal uterine bleeding or functional bleeding with correct histopathological findings.