Open AccessExpression pattern of circadian rhythm-related genes and its potential relationship with miRNAs activity in endometrial cancer
Author(s) -
Ewelina Hermyt,
Nikola Zmarzły,
Celina KruszniewskaRajs,
Joanna Gola,
Agnieszka Jeda-Golonka,
Katarzyna Szczepanek,
Urszula Mazurek,
Andrzej Witek
Publication year - 2023
Publication title -
ginekologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 21
eISSN - 2543-6767
pISSN - 0017-0011
DOI - 10.5603/gp.a2022.0063
Subject(s) - circadian rhythm , microrna , endometrial cancer , gene silencing , clock , circadian clock , carcinogenesis , biology , cancer , gene expression , dna microarray , cancer research , medicine , endocrinology , gene , genetics
The circadian clock is an autonomous oscillator that controls key aspects of cell physiology, including metabolism, transcriptional state, and cell signaling. Disturbances of circadian rhythms lead to disruption of cell and tissue homeostasis, which promotes carcinogenesis. The aim of the study was to determine the expression of circadian rhythm-related genes in endometrial cancer and to select miRNAs involved in the regulation of their expression.