Open AccessHyperthyroidism secondary to a hydatidiform mole
Author(s) -
Barbara Grzechocińska,
Małgorzata Gajewska,
Maciej Kędzierski,
Sylwia Gajda,
Piotr Jedrzejak,
Mirosław Wielgoś
Publication year - 2021
Publication title -
ginekologia polska
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 21
eISSN - 2543-6767
pISSN - 0017-0011
DOI - 10.5603/gp.a2021.0185
Subject(s) - gestational trophoblastic disease , medicine , hormone , trophoblast , mole , thyroid , endocrinology , human chorionic gonadotropin , endocrine system , gonadotropin , pregnancy , fetus , placenta , gestation , biology , genetics
The case presented in the article is that of a 47-year-old female patient with hyperthyroidism induced by a hydatidiform mole. Attention was drawn to the necessity of preparing the patient for a procedure with drugs that stabilize the hormonal activity of the thyroid. The removal of the hydatidiform mole resulted in gradual normalization of thyroid hormone levels. The trophoblast has a hormonal activity, secrete hCG (human chorionic gonadotropin).The hCG partial structural homology causes affinity to the TSH (thyroid stimulating hormone) receptor. The higher the weight of the trophoblast, the higher the production and concentration of hCG in the blood. Therefore, gestational trophoblastic disease may be accompanied by hyperthyroidism. The problem is frequently described, however, due to the risk of developing thyroid storm, it cannot be overlooked [1].