Open AccessFokI vitamin D receptor polymorphism as a protective factor in intrahepatic cholestasis of pregnancy
Author(s) -
Hubert Wolski,
Grażyna Kurzawińska,
Marcin Ożarowski,
Krzysztof Drews,
Magdalena Barlik,
Katarzyna Piątek,
Zbyszko Malewski,
A Mrozikiewicz,
Justyna Magiełda-Stola,
Dorota Kolanowska,
Marlena Wolek,
Agnieszka SeremakMrozikiewicz
Publication year - 2020
Publication title -
ginekologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 21
eISSN - 2543-6767
pISSN - 0017-0011
DOI - 10.5603/gp.a2020.0135
Subject(s) - foki , calcitriol receptor , taqi , medicine , cholestasis of pregnancy , genotype , single nucleotide polymorphism , endocrinology , population , vitamin d and neurology , pregnancy , polymorphism (computer science) , genetics , fetus , gene , biology , environmental health
Intrahepatic cholestasis in pregnancy (ICP) is a pregnancy-specific liver disorder. Its etiology is not fully understood. Increasing evidence indicates the important role of vitamin D and the vitamin D receptor (VDR) in this disorder. The presence of polymorphic variants in the VDR gene could influence its activity and susceptibility to ICP development. The goal of the study was to investigate the role of four genetic polymorphisms of the VDR gene - Fok (rs731236), Bsm (rs1544410), Apa (rs7975232), and Taq (rs731236) - in the etiology of ICP in Polish women.