Open AccessExpression profiling of genes modulated by rosmarinic acid (RA) in MCF-7 breast cancer cells
Author(s) -
Bogna Juskowiak,
Anna Bogacz,
Marlena Wolek,
Adam Kamiński,
Izabela Uzar,
Agnieszka SeremakMrozikiewicz,
Bogusław Czerny
Publication year - 2018
Publication title -
ginekologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 21
eISSN - 2543-6767
pISSN - 0017-0011
DOI - 10.5603/gp.a2018.0092
Subject(s) - mcf 7 , rosmarinic acid , medicine , profiling (computer programming) , breast cancer , gene , gene expression profiling , cancer research , oncology , gene expression , cancer , human breast , genetics , biochemistry , biology , antioxidant , computer science , operating system
Cancer is the second most common cause of death, with breast cancer (BC) as the most frequently diagnosed neoplasm among females. The origin of BC is multifactorial and depends on environmental and genetic factors. The disease presents a significant challenge due to its drug resistance and frequent metastasis. Thus, new effective therapies and metastasis prevention are much needed. Rosmarinic acid (RA) is a natural polyphenol which possesses the ability to inhibit BC cell proliferation and demonstrates cytotoxic properties against those cells. In our study, we examined the effect of RA on the expression of ZEB1, MDM2, ABCB1, PTEN and TWIST1 genes in MCF-7 breast cancer cells.