Curcumin reduces blood-nerve barrier abnormalities and cytotoxicity to endothelial cells and pericytes induced by cisplatin | Zendy

Phetnarin Kobutree | Zendy; Amornrat Tothonglor | Zendy; Atitaya Roumwong | Zendy; Depicha Jindatip | Zendy; Sithiporn Agthong | Zendy

Open Access

Curcumin reduces blood-nerve barrier abnormalities and cytotoxicity to endothelial cells and pericytes induced by cisplatin

Author(s) -

Phetnarin Kobutree,

Amornrat Tothonglor,

Atitaya Roumwong,

Depicha Jindatip,

Sithiporn Agthong

Publication year - 2022

Publication title -

folia morphologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.333

H-Index - 30

eISSN - 1644-3284

pISSN - 0015-5659

DOI - 10.5603/fm.a2022.0065

Subject(s) - cisplatin , curcumin , pericyte , occludin , oxidative stress , pharmacology , tight junction , cytotoxicity , peripheral neuropathy , medicine , pathology , chemistry , cancer research , endocrinology , endothelial stem cell , biochemistry , chemotherapy , in vitro , diabetes mellitus

Cisplatin is a platinum-based antineoplastic agent used to treat cancers of solid organs. Neuropathy is one of its major side effects, necessitating dose reduction or cessation. Previous studies suggested that cisplatin causes microvascular toxicity, including pericyte detachment. This study aimed to clarify whether these alterations occurred in the blood-nerve barrier (BNB) of capillaries after cisplatin treatment.

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