Open AccessCurcumin reduces blood-nerve barrier abnormalities and cytotoxicity to endothelial cells and pericytes induced by cisplatin
Author(s) -
Phetnarin Kobutree,
Amornrat Tothonglor,
Atitaya Roumwong,
Depicha Jindatip,
Sithiporn Agthong
Publication year - 2023
Publication title -
folia morphologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.333
H-Index - 30
eISSN - 1644-3284
pISSN - 0015-5659
DOI - 10.5603/fm.a2022.0065
Subject(s) - cisplatin , curcumin , pericyte , occludin , oxidative stress , pharmacology , tight junction , cytotoxicity , peripheral neuropathy , medicine , pathology , chemistry , cancer research , endocrinology , endothelial stem cell , biochemistry , chemotherapy , in vitro , diabetes mellitus
Cisplatin is a platinum-based antineoplastic agent used to treat cancers of solid organs. Neuropathy is one of its major side effects, necessitating dose reduction or cessation. Previous studies suggested that cisplatin causes microvascular toxicity, including pericyte detachment. This study aimed to clarify whether these alterations occurred in the blood-nerve barrier (BNB) of capillaries after cisplatin treatment.