The role of the adipose tissue-derived mesenchymal stem cells enriched with melatonin in pancreatic cellular regeneration | Zendy

H. El Aasar | Zendy; Laila A. Rashed | Zendy; Abir El Sadik | Zendy; Rabah Amer | Zendy; H. Emam | Zendy

Open Access

The role of the adipose tissue-derived mesenchymal stem cells enriched with melatonin in pancreatic cellular regeneration

Author(s) -

H. El Aasar,

Laila A. Rashed,

Abir El Sadik,

Rabah Amer,

H. Emam

Publication year - 2021

Publication title -

folia morphologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.333

H-Index - 30

eISSN - 1644-3284

pISSN - 0015-5659

DOI - 10.5603/fm.a2021.0093

Subject(s) - mesenchymal stem cell , streptozotocin , pancreas , adipose tissue , islet , endocrinology , medicine , stem cell , insulin , biology , melatonin , regeneration (biology) , microbiology and biotechnology , diabetes mellitus

Adipose tissue-derived mesenchymal stem cells (AD-MSCs) were proved to differentiate into insulin-producing cells (IPCs), but the amount of insulin secreted was relatively low compared to the insulin secreted by mature pancreatic islets. Enrichment of MSCs culture with melatonin (MT) was found to promote cartilage matrix synthesis, osteogenic and neuronal differentiation. Therefore, the present study was conducted to evaluate the potential role of MT pre-treated AD-MSCs in enhancing the treatment and regeneration of the islet cells of Langerhans in rats with diabetes induced by streptozotocin (STZ).

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