Open AccessThe role of the adipose tissue-derived mesenchymal stem cells enriched with melatonin in pancreatic cellular regeneration
Author(s) -
H. El Aasar,
Laila A. Rashed,
Abir El Sadik,
R. Amer,
H. Emam
Publication year - 2022
Publication title -
folia morphologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.333
H-Index - 30
eISSN - 1644-3284
pISSN - 0015-5659
DOI - 10.5603/fm.a2021.0093
Subject(s) - mesenchymal stem cell , streptozotocin , pancreas , adipose tissue , islet , endocrinology , medicine , stem cell , insulin , biology , melatonin , regeneration (biology) , microbiology and biotechnology , diabetes mellitus
Adipose tissue-derived mesenchymal stem cells (AD-MSCs) were proved to differentiate into insulin-producing cells (IPCs), but the amount of insulin secreted was relatively low compared to the insulin secreted by mature pancreatic islets. Enrichment of MSCs culture with melatonin (MT) was found to promote cartilage matrix synthesis, osteogenic and neuronal differentiation. Therefore, the present study was conducted to evaluate the potential role of MT pre-treated AD-MSCs in enhancing the treatment and regeneration of the islet cells of Langerhans in rats with diabetes induced by streptozotocin (STZ).