Open AccessPreventive effects of bone marrow-derived mesenchymal stem cell transplantation in a D-galactose-induced brain aging in rats
Author(s) -
Gehan El–Akabawy,
Kawther Aabed,
Laila Ahmed Rashed,
Shaimaa Nasr Amin,
Ilhaam Alsaati,
Musaad Alfayez
Publication year - 2022
Publication title -
folia morphologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.333
H-Index - 30
eISSN - 1644-3284
pISSN - 0015-5659
DOI - 10.5603/fm.a2021.0073
Subject(s) - mesenchymal stem cell , choline acetyltransferase , neurotrophic factors , stem cell , transplantation , brain derived neurotrophic factor , hippocampal formation , biology , bone marrow , cholinergic , hippocampus , cholinergic neuron , endocrinology , neuroscience , basal forebrain , medicine , microbiology and biotechnology , receptor
Aging is a complex process accompanied by numerous morphological, functional, and metabolic impairments in the brain, and a critical risk factor involved in the increasing incidence of neurodegenerative diseases. Few studies have evaluated the efficacy of different sources of mesenchymal stem cells (MSCs) in ameliorating the early morphological and functional alterations in the aging brain. This study, for the first time, evaluated the potential efficacy of intravenous injection of bone marrow-derived mesenchymal stem cells (BMMSCs) in a D-galactose-induced rat model of brain aging.