Open AccessThe influence of functional pinealectomy and exogenous melatonin application on healing of a burr hole in adult rat calvaria: a histological and immunohistochemical study
Author(s) -
Hulki Başaloğlu,
Mehmet Turğut,
Cansın Şirin,
Yiğit Uyanıkgil,
Buket Demirci,
Emel Dikicioğlu Çetin
Publication year - 2022
Publication title -
folia morphologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.333
H-Index - 30
eISSN - 1644-3284
pISSN - 0015-5659
DOI - 10.5603/fm.a2021.0047
Subject(s) - pinealectomy , calvaria , melatonin , connective tissue , h&e stain , medicine , bone healing , haematoxylin , immunohistochemistry , pathology , anatomy , endocrinology , chemistry , pineal gland , biochemistry , in vitro
Even today, repair of the cranial defects still represents a significant challenge in neurosurgery and various options have been used for their reconstruction to date. However, there are very few studies investigating the effects of exogenous administration of melatonin (MEL) as an agent that promotes bone regeneration. The goal of this study was to investigate the effects of functional pinealectomy (Px) and exogenous MEL administration on the bone repair properties and surrounding connective tissue alterations in a rat calvaria model.