Open AccessBiochemical and immunohistochemical investigations on bone formation and remodelling in ovariectomised rats with tamoxifen citrate administration
Author(s) -
Murat Baloğlu,
Ebru Gökalp Özkorkmaz
Publication year - 2019
Publication title -
folia morphologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.333
H-Index - 30
eISSN - 1644-3284
pISSN - 0015-5659
DOI - 10.5603/fm.a2019.0035
Subject(s) - endocrinology , medicine , osteopontin , tamoxifen , bone remodeling , osteonectin , bone resorption , osteoporosis , osteoblast , chemistry , alkaline phosphatase , osteocalcin , biochemistry , cancer , breast cancer , in vitro , enzyme
Osteoporosis results with the imbalance between osteoblastic formation and osteoclastic resorption, resulting in susceptibility to bone fractures. Ovariectomy leads to osteoporosis by triggering alterations in bone formation and structure. Tamoxifen as an anti-oestrogen is used for adjuvant therapy especially in metastatic diseases and known to have a bone mass protective effect after ovariectomy.