Open AccessPsoralen inhibits the proliferation and promotes apoptosis through endoplasmic reticulum stress in human osteosarcoma cells
Author(s) -
Shubo Li,
Hongqin Tu
Publication year - 2022
Publication title -
folia histochemica et cytobiologica
Language(s) - English
Resource type - Journals
eISSN - 1897-5631
pISSN - 0239-8508
DOI - 10.5603/fhc.a2022.0010
Subject(s) - psoralen , viability assay , apoptosis , cell cycle , chemistry , cell growth , endoplasmic reticulum , psoralea corylifolia , mtt assay , microbiology and biotechnology , biology , biochemistry , medicine , pathology , dna , alternative medicine
Psoralen is a main active component of Psoralea corylifolia Linn. (Leguminosae). Psoralen has been reported to show antitumor effects and activity to accelerate osteoblastic proliferation. Nevertheless, the antitumor mechanism of psoralen in osteosarcoma has never been elucidated. The current study is aimed to investigate the therapeutic function of psoralen in human osteosarcoma cells and its potential regulatory mechanism.