Open AccessWnt/PCP pathway regulates the migration and neural differentiation of mesenchymal stem cells in vitro
Author(s) -
Panpan Yao,
Yu Q,
Lujie Zhu,
Jingxian Li,
Xueyuan Zhou,
Lili Wu,
Yi Cai,
Hongmei Shen,
Liping Zhou
Publication year - 2022
Publication title -
folia histochemica et cytobiologica
Language(s) - English
Resource type - Journals
eISSN - 1897-5631
pISSN - 0239-8508
DOI - 10.5603/fhc.a2022.0006
Subject(s) - mesenchymal stem cell , wnt3a , rhoa , neural stem cell , wnt signaling pathway , microbiology and biotechnology , homing (biology) , nestin , chemistry , stem cell , biology , signal transduction , ecology
Mesenchymal stem cells (MSCs) are an excellent donor graft source due to their potential for self-renewal and multidirectional differentiation. However, the potential mechanisms involved in MSC homing and neural differentiation are still unclear. The purpose of this study was to explore the effects of a chemokine, SDF-1a, and Wnt3a ligand on rat MSCs' migration and b-mercaptoethanol (BME)-induced neural differentiation of MSCs.