Wnt/PCP pathway regulates the migration and neural differentiation of mesenchymal stem cells in vitro | Zendy

Panpan Yao | Zendy; Qin Yu | Zendy; Lujie Zhu | Zendy; Jingxian Li | Zendy; Xueyuan Zhou | Zendy; Lili Wu | Zendy; Yongyi Cai | Zendy; Hongmei Shen | Zendy; Liping Zhou | Zendy

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Wnt/PCP pathway regulates the migration and neural differentiation of mesenchymal stem cells in vitro

Author(s) -

Panpan Yao,

Qin Yu,

Lujie Zhu,

Jingxian Li,

Xueyuan Zhou,

Lili Wu,

Yongyi Cai,

Hongmei Shen,

Liping Zhou

Publication year - 2022

Publication title -

folia histochemica et cytobiologica

Language(s) - English

Resource type - Journals

eISSN - 1897-5631

pISSN - 0239-8508

DOI - 10.5603/fhc.a2022.0006

Subject(s) - mesenchymal stem cell , wnt3a , rhoa , neural stem cell , wnt signaling pathway , microbiology and biotechnology , homing (biology) , nestin , chemistry , stem cell , biology , signal transduction , ecology

Mesenchymal stem cells (MSCs) are an excellent donor graft source due to their potential for self-renewal and multidirectional differentiation. However, the potential mechanisms involved in MSC homing and neural differentiation are still unclear. The purpose of this study was to explore the effects of a chemokine, SDF-1a, and Wnt3a ligand on rat MSCs' migration and b-mercaptoethanol (BME)-induced neural differentiation of MSCs.

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