Open AccessSDF-1/CXCR4 axis promotes osteogenic differentiation of BMSCs through the JAK2/STAT3 pathway
Author(s) -
Xiong Wen,
Xin Guo,
Xianhua Cai
Publication year - 2021
Publication title -
folia histochemica et cytobiologica
Language(s) - English
Resource type - Journals
eISSN - 1897-5631
pISSN - 0239-8508
DOI - 10.5603/fhc.a2021.0020
Subject(s) - runx2 , stat3 , stromal cell , chemistry , mesenchymal stem cell , stat protein , osteocalcin , microbiology and biotechnology , cellular differentiation , janus kinase 2 , signal transduction , transcription factor , cancer research , biology , alkaline phosphatase , biochemistry , gene , enzyme
This study aimed to investigate the effects of stromal cell-derived factor-1 (SDF-1) and activation of its receptor, chemokine receptor 4 (CXCR4), on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and the key signaling mechanisms involved in these effects.