SDF-1/CXCR4 axis promotes osteogenic differentiation of BMSCs through the JAK2/STAT3 pathway | Zendy

Xiong Wen | Zendy; Xin Guo | Zendy; Xianhua Cai | Zendy

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SDF-1/CXCR4 axis promotes osteogenic differentiation of BMSCs through the JAK2/STAT3 pathway

Author(s) -

Xiong Wen,

Xin Guo,

Xianhua Cai

Publication year - 2021

Publication title -

folia histochemica et cytobiologica

Language(s) - English

Resource type - Journals

eISSN - 1897-5631

pISSN - 0239-8508

DOI - 10.5603/fhc.a2021.0020

Subject(s) - runx2 , stat3 , stromal cell , chemistry , mesenchymal stem cell , stat protein , osteocalcin , microbiology and biotechnology , cellular differentiation , janus kinase 2 , signal transduction , transcription factor , cancer research , biology , alkaline phosphatase , biochemistry , gene , enzyme

This study aimed to investigate the effects of stromal cell-derived factor-1 (SDF-1) and activation of its receptor, chemokine receptor 4 (CXCR4), on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and the key signaling mechanisms involved in these effects.

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