Open AccessAstragalus polysaccharide protects formaldehyde-induced toxicity by promoting NER pathway in bone marrow mesenchymal stem cells
Author(s) -
Yali She,
Xiaowen Zhao,
Pingfan Wu,
Ling Xue,
Zhe Liu,
Meng Zhu,
Jie Yang,
Yaling Li
Publication year - 2021
Publication title -
folia histochemica et cytobiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.384
H-Index - 40
eISSN - 1897-5631
pISSN - 0239-8508
DOI - 10.5603/fhc.a2021.0013
Subject(s) - xeroderma pigmentosum , microbiology and biotechnology , ercc1 , comet assay , cytotoxicity , nucleotide excision repair , dna damage , genotoxicity , chemistry , dna repair , mtt assay , micronucleus test , biology , in vitro , dna , biochemistry , toxicity , organic chemistry
In our previous study, it has been confirmed that formaldehyde (FA) not only inhibits the proliferative activity, but also causes DNA-protein crosslinks (DPCs) formation in bone marrow mesenchymal stem cells (BMSCs). The purpose of this study was to detect the protective effect of astragalus polysaccharide (APS) against the cytotoxicity and genotoxicity of BMSCs exposed to FA, and to explore potential molecular mechanisms of APS activity.