Open AccessRepeated isoflurane exposures of neonatal rats contribute to cognitive dysfunction in juvenile animals: the role of miR-497 in isoflurane-induced neurotoxicity
Author(s) -
Yuanyuan Que,
Fangxiang Zhang,
Jing Peng,
Zhuhua Zhang,
Duwen Zhang,
Ming-Hai He
Publication year - 2021
Publication title -
folia histochemica et cytobiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.384
H-Index - 40
eISSN - 1897-5631
pISSN - 0239-8508
DOI - 10.5603/fhc.a2021.0011
Subject(s) - isoflurane , neurotoxicity , hippocampal formation , morris water navigation task , hippocampus , viability assay , apoptosis , western blot , neuroprotection , biology , chemistry , medicine , pharmacology , anesthesia , endocrinology , toxicity , biochemistry , gene
Isoflurane anesthesia at the period of brain development can lead to neurotoxicity and long-term cognitive impairment. This study aimed to investigate the role of miR-497 on isoflurane-induced neurotoxicity.