Repeated isoflurane exposures of neonatal rats contribute to cognitive dysfunction in juvenile animals: the role of miR-497 in isoflurane-induced neurotoxicity | Zendy

Yuanyuan Que | Zendy; Fangxiang Zhang | Zendy; Jing Peng | Zendy; Shuyang Zhang | Zendy; Duwen Zhang | Zendy; Ming-Hai He | Zendy

Open Access

Repeated isoflurane exposures of neonatal rats contribute to cognitive dysfunction in juvenile animals: the role of miR-497 in isoflurane-induced neurotoxicity

Author(s) -

Yuanyuan Que,

Fangxiang Zhang,

Jing Peng,

Shuyang Zhang,

Duwen Zhang,

Ming-Hai He

Publication year - 2021

Publication title -

folia histochemica et cytobiologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.384

H-Index - 40

eISSN - 1897-5631

pISSN - 0239-8508

DOI - 10.5603/fhc.a2021.0011

Subject(s) - isoflurane , neurotoxicity , hippocampal formation , morris water navigation task , hippocampus , viability assay , apoptosis , western blot , neuroprotection , biology , chemistry , medicine , pharmacology , anesthesia , endocrinology , toxicity , biochemistry , gene

Isoflurane anesthesia at the period of brain development can lead to neurotoxicity and long-term cognitive impairment. This study aimed to investigate the role of miR-497 on isoflurane-induced neurotoxicity.

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