Open AccessThe protective impact of Trans-Cinnamaldehyde (TCA) against the IL-1b induced inflammation in in vitro osteoarthritis model by regulating PI3K/AKT pathways
Author(s) -
Jianrong Wu,
Wenjie Zhong,
Zhendong Chen,
Ben-Qi Zhu,
Yunyun Jiang,
Piotr Wierzbicki
Publication year - 2020
Publication title -
folia histochemica et cytobiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.384
H-Index - 40
eISSN - 1897-5631
pISSN - 0239-8508
DOI - 10.5603/fhc.a2020.0025
Subject(s) - protein kinase b , apoptosis , osteoarthritis , pi3k/akt/mtor pathway , chemistry , inflammation , viability assay , proinflammatory cytokine , pharmacology , cancer research , medicine , immunology , biochemistry , pathology , alternative medicine
Osteoarthritis (OA) is a severe joint degeneration disease in elderly people described by the advanced degradation of articular cartilage, which ultimately leads to chronic pain. Trans-cinnamaldehyde (TCA) exerted its anti-inflammatory function in numerous disease syndromes; however, its role in the pathogenesis of OA remains unknown. The current research aimed to explore the potential protective impact of TCA in the progression of osteoarthritis in vitro.