Open AccessSearch of reference biomarkers reflecting orbital tissue remodeling in the course of Graves’ orbitopathy
Author(s) -
Przemysław Pawlowski,
Izabela Poplawska,
Janusz Myśliwiec,
Willem A. Dik,
Anja Eckstein,
Utta BerchnerPfannschmidt,
Robert Milewski,
Sławomir Ławicki,
Zofia Dzięcioł-Anikiej,
Robert Ręjdak,
Joanna Reszeć
Publication year - 2020
Publication title -
folia histochemica et cytobiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.384
H-Index - 40
eISSN - 1897-5631
pISSN - 0239-8508
DOI - 10.5603/fhc.a2020.0003
Subject(s) - graves' ophthalmopathy , cd68 , fibrosis , cd34 , medicine , immunohistochemistry , pathology , adipose tissue , atrophy , pathogenesis , graves' disease , disease , stem cell , biology , microbiology and biotechnology
Graves' orbitopathy (GO) is a complication in Graves' disease (GD) that causes disfigurement and sometimes blindness. The pathogenesis of GO remains unknown, while its symptoms demonstrate dependence between the thyroid gland and the orbit. The ongoing inflammatory process in retrobulbar tissue results in its remodeling characterized by increased volume of the orbital contents involving adipose tissue, with fibrosis and adipogenesis as predominant features. This study was aimed at the immunohistochemical verification of potential contribution and correlation between orbital expressions of IGF-1R, CD34, Foxp-3, PPAR-γ and CD4, CD68, TGF-β, FGF-β in severe and mild (long-lasting) GO.