Open AccessDecreased expression of p73 in colorectal cancer
Author(s) -
Anna Kotulak,
Agata Wrońska,
Jarosław Kobiela,
Janusz Godlewski,
Marcin Stanisławowski,
Piotr M. Wierzbicki
Publication year - 2016
Publication title -
folia histochemica et cytobiologica
Language(s) - English
Resource type - Journals
eISSN - 1897-5631
pISSN - 0239-8508
DOI - 10.5603/fhc.a2016.0018
Subject(s) - colorectal cancer , immunohistochemistry , gene isoform , messenger rna , submucosa , cancer , biology , pathology , gene expression , pathological , pathogenesis , blot , cancer research , biomarker , microbiology and biotechnology , real time polymerase chain reaction , gene , medicine , genetics
The colorectal cancer (CRC) is one of the most frequent cancer in Poland and worldwide. This disease is characterized by distinct genetic alterations. p73 belongs to the p53 gene family; however, its role in the pathogenesis of CRC has not been completely understood. p73 gene encodes several mRNA variants and protein isoforms with its longest and fully functional p73a (mRNA) and TAp73a (protein) isoform. The aim of the study was to investigate p73 gene expression at the mRNA (p73a) and protein (TAp73a) levels in CRC.