Open AccessThe Impact of Dicer, Drosha and Exportin-5 levels in Polycystic Ovary Syndrome (PCOS) Diagnosis and Phenotyping
Author(s) -
Gülhan Duman,
Barış Sarıakçalı,
Serpil Erşan,
Sevtap Bakır
Publication year - 2021
Publication title -
endokrynologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.413
H-Index - 27
eISSN - 2299-8306
pISSN - 0423-104X
DOI - 10.5603/ep.a2021.0096
Subject(s) - polycystic ovary , drosha , dicer , hirsutism , infertility , medicine , gynecology , disease , endocrinology , biology , pregnancy , genetics , insulin resistance , obesity , rna , small interfering rna , transfection , rna interference , gene , cell culture
Polycystic ovary syndrome (PCOS) is a very common heterogeneous endocrine and gynaecological disease in reproductive women. Early identification and treatment of patients are necessary to prevent future cardiometabolic and reproductive complications. In our study, we aimed to investigate whether Drosha, Exportin-5 (XPO5), and Dicer, which are involved in miRNA formation, are useful markers in the diagnosis of the disease.