Open AccessImmunotherapy with a biologically active ICAM-1 mAb and an siRNA targeting TSHR in a BALB/c mouse model of Graves’ disease
Author(s) -
Xuan Wang,
Wei Liu,
Zhongying Rui,
Wei Zheng,
Jian Tan,
Ning Li,
Yang Yu
Publication year - 2021
Publication title -
endokrynologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.413
H-Index - 27
eISSN - 2299-8306
pISSN - 0423-104X
DOI - 10.5603/ep.a2021.0087
Subject(s) - monoclonal antibody , medicine , antibody , thyroid , pharmacology , graves' disease , immunotherapy , icam 1 , immunology , endocrinology , immune system , cell adhesion molecule
The objective was to study targeted therapies using a biologically active monoclonal antibody against intracellular adhesion molecule-1 (ICAM-1 mAb) and an siRNA targeting thyroid-stimulating hormone (TSH) receptor (TSHR) in a BALB/c mouse model of Graves' disease (GD).