Open AccessPEDF relieves kidney injury in type 2 diabetic nephropathy mice by reducing macrophage infiltration
Author(s) -
Li Li,
Lan Zhang,
Danyan Chen,
Keping Yu,
Hua Gan,
Gangyi Yang
Publication year - 2021
Publication title -
endokrynologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.413
H-Index - 27
eISSN - 2299-8306
pISSN - 0423-104X
DOI - 10.5603/ep.a2021.0085
Subject(s) - pedf , diabetic nephropathy , endocrinology , diabetes mellitus , medicine , nephropathy , kidney , blood urea nitrogen , creatinine , angiogenesis
Pigment epithelium-derived factor (PEDF) is a multifunctional protein with anti-angiogenic, antioxidant and anti-inflammatory properties. PEDF is involved in the pathogenesis of diabetic retinopathy, but its exact role in diabetic kidneys remains unclear. P78-PEDF is an active peptide sequence consisting of 44 amino acids with biological activity similar to that of PEDF. The present study aimed to investigate whether PEDF can alleviate renal damage in type 2 diabetic nephropathy mice by inhibiting macrophage infiltration.