Open AccessEvaluation of the frequency of ADIPOQ c.45 T>G and ADIPOQ c.276 G>T polymorphisms in adiponectin coding gene in girls with anorexia nervosa
Author(s) -
Karolina Ziora-Jakutowicz,
Janusz Zimowski,
Katarzyna Ziora,
Małgorzata Bednarska-Makaruk,
Elżbieta Świętochowska,
Piotr Gorczyca,
Maria Szczepańska,
Edyta Machura,
Małgorzata Stojewska,
Katarzyna Gołąb-Jenerał,
Małgorzata Blaska,
Elżbieta Mizgała-Izworska,
Michał Kukla,
Filip Rybakowski
Publication year - 2021
Publication title -
endokrynologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.413
H-Index - 27
eISSN - 2299-8306
pISSN - 0423-104X
DOI - 10.5603/ep.a2021.0064
Subject(s) - adiponectin , medicine , endocrinology , genotype , insulin resistance , obesity , genetics , biology , gene
Anorexia nervosa (AN) is a serious chronic psychosomatic disorder, the essence of which are attempts by the sufferer to obtain a slim silhouette by deliberate weight loss (restrictive diet, strenuous physical exercise, provoking vomiting). The aetiology of this disorder is multifactorial. Genetic factors that influence the predisposition to AN have been sought. A broad meta-analysis points to a strong genetic correlation between AN and insulin resistance. Adiponectin (ADIPO) increases insulin sensitivity. In our pilot study we demonstrated that the TT genotype in locus ADIPOQ c.276 G>T of the ADIPO gene and a higher concentration of ADIPO in blood serum occurred significantly more frequently in 68 girls suffering from AN than in 38 healthy girls. The objective of this study was to evaluate the frequency of the occurrence of ADIPOQ c.45 T>G and ADIPOQ c.276 G>T in the ADIPO gene in a larger cohort of girls with AN and healthy girls, as well as an analysis of correlations between variants of the aforementioned polymorphisms and the levels of ADIPO in blood serum.