Open AccessExogenous orexin-A downregulates luteinizing hormone secretory activity in prepubertal female rats
Author(s) -
Lidia Martyńska,
Alina Gajewska,
Magdalena Chmielowska,
Małgorzata Kalisz,
Anna Litwiniuk,
Wojciech Bik,
B Baranowska
Publication year - 2021
Publication title -
endokrynologia polska
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.413
H-Index - 27
eISSN - 2299-8306
pISSN - 0423-104X
DOI - 10.5603/ep.a2021.0041
Subject(s) - medicine , endocrinology , orexin , orexin a , orexin receptor , hypothalamus , neuropeptide , antagonist , microinjection , lateral hypothalamus , chemistry , luteinizing hormone , receptor , galanin , hormone , biology
Orexin-A is a neuropeptide synthesized in the lateral hypothalamus. Orexin-A immunoreactive fibres overlap distribution with GnRH neurons. In adult rats, orexin A is known to affect LH secretion via GnRH release modulation. Because data concerning the impact of orexin-A on the hypothalamo-pituitary axis activity are limited, we focused on the involvement of orexin-A and receptors of NPY in the modulation of LH release and LH subunit b (Lhb) mRNA expression in prepubertal female rats.