Open AccessParathyroid hormone serum concentration kinetic profile in critically ill patients undergoing continuous renal replacement therapies: a prospective observational study
Author(s) -
Aneta Czarnik,
Ryszard Gawda,
Maciej Piwoda,
Maciej Marszalski,
Maciej Molsa,
Marek Pietka,
Marek Bolanowski,
Tomasz Czarnik
Publication year - 2021
Publication title -
endokrynologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.413
H-Index - 27
eISSN - 2299-8306
pISSN - 0423-104X
DOI - 10.5603/ep.a2021.0034
Subject(s) - medicine , intensive care unit , renal replacement therapy , parathyroid hormone , acute kidney injury , intensive care , kidney disease , sofa score , prospective cohort study , urology , intensive care medicine , calcium
Elevated serum parathormone (PTH) levels have been observed in acute kidney injury and are related to calcium-phosphate metabolism disturbance, decreased renal production of 1,25 dihydroxyvitamin D3, impaired renal PTH excretion, and other renal-independent factors. There are no data regarding PTH concentration kinetics in critically ill patients undergoing continuous renal replacement therapies (CRRT) in an intensive care setting. The primary objective of this study was to investigate trends in PTH serum levels in critically ill patients with multiorgan failure undergoing CRRT, by performing periodic PTH measurements in the acute phase of critical illness.