Open AccessTGF-β1, metabolizm kostny, osteoprotegeryna i rozpuszczalny ligand receptora aktywatora czynnika jądrowego-B u dziewcząt z jadłowstrętem psychicznym
Author(s) -
Zofia Ostrowska,
Katarzyna Ziora,
Joanna Oświęcimska,
Elżbieta Świętochowska,
Bogdan Marek,
Dariusz Kajdaniuk,
Joanna Katarzyna Strzelczyk,
Karolina Gołąbek,
Kinga Wołkowska-Pokrywa,
Beata KosKudła
Publication year - 2016
Publication title -
endokrynologia polska
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.413
H-Index - 27
eISSN - 2299-8306
pISSN - 0423-104X
DOI - 10.5603/ep.a2016.0059
Subject(s) - medicine , endocrinology , bone remodeling , transforming growth factor , osteoprotegerin , receptor , cytokine , body mass index , anorexia nervosa , chemistry , eating disorders , psychiatry , activator (genetics)
Numerous investigations, and especially in vitro studies, indicate that TGF-β1 may act as an important regulator of bone remodelling. Thus, it could be expected that disturbances of this cytokine production observed by several researchers might play a role in the mechanism leading to the development of osteoporosis in girls with anorexia nervosa (AN). The aim of the study was to determine whether 1) girls with AN exhibited a relationship between TGF-β1 and bone metabolism (as assessed based on serum OC and CTx concentrations) and 2) whether OPG and sRANKL might modify the possible relationship between TGF-β1 and bone metabolism.