TGF-β1, metabolizm kostny, osteoprotegeryna i rozpuszczalny ligand receptora aktywatora czynnika jądrowego-B u dziewcząt z jadłowstrętem psychicznym | Zendy

Zofia Ostrowska | Zendy; Katarzyna Ziora | Zendy; Joanna Oświęcimska | Zendy; Elżbieta Świętochowska | Zendy; Bogdan Marek | Zendy; Dariusz Kajdaniuk | Zendy; Joanna Katarzyna Strzelczyk | Zendy; Karolina Gołąbek | Zendy; Kinga Wołkowska-Pokrywa | Zendy; Beata KosKudła | Zendy

Open Access

TGF-β1, metabolizm kostny, osteoprotegeryna i rozpuszczalny ligand receptora aktywatora czynnika jądrowego-B u dziewcząt z jadłowstrętem psychicznym

Author(s) -

Zofia Ostrowska,

Katarzyna Ziora,

Joanna Oświęcimska,

Elżbieta Świętochowska,

Bogdan Marek,

Dariusz Kajdaniuk,

Joanna Katarzyna Strzelczyk,

Karolina Gołąbek,

Kinga Wołkowska-Pokrywa,

Beata KosKudła

Publication year - 2016

Publication title -

endokrynologia polska

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.413

H-Index - 27

eISSN - 2299-8306

pISSN - 0423-104X

DOI - 10.5603/ep.a2016.0059

Subject(s) - medicine , endocrinology , bone remodeling , transforming growth factor , osteoprotegerin , receptor , cytokine , body mass index , anorexia nervosa , chemistry , eating disorders , psychiatry , activator (genetics)

Numerous investigations, and especially in vitro studies, indicate that TGF-β1 may act as an important regulator of bone remodelling. Thus, it could be expected that disturbances of this cytokine production observed by several researchers might play a role in the mechanism leading to the development of osteoporosis in girls with anorexia nervosa (AN). The aim of the study was to determine whether 1) girls with AN exhibited a relationship between TGF-β1 and bone metabolism (as assessed based on serum OC and CTx concentrations) and 2) whether OPG and sRANKL might modify the possible relationship between TGF-β1 and bone metabolism.

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