Open AccessOcena stężenia produków zaawansowanej glikacji białek i przeciwciał anty-CEL i anty-CML w surowicy pacjentów chorujących na orbitopatię Gravesa przed i po leczeniu metyloprednizolonem
Author(s) -
Janusz Strzelczyk,
Magdalena Szumska,
Aleksandra Damasiewicz-Bodzek,
Anna Krywult,
Michał Długaszek,
Justyna Czubilińska,
Kaja Gawlik,
Konrad Synowiec,
Krystyna Tyrpień-Golder,
Karolina Poczkaj,
Beata KosKudła
Publication year - 2015
Publication title -
endokrynologia polska
Language(s) - Polish
Resource type - Journals
SCImago Journal Rank - 0.413
H-Index - 27
eISSN - 2299-8306
pISSN - 0423-104X
DOI - 10.5603/ep.a2016.0047
Subject(s) - glycation , chemistry , lysine , antibody , medicine , endocrinology , biochemistry , immunology , receptor , amino acid
The glycation process is a non-enzymatic modification of proteins occurring due to the reactions of reductive carbohydrates. The glycated residues lose their biological functions, and their removal process is ineffective. They accumulate, and as a result they cause an immunological response. The aim of this study was a determination of the concentrations of advanced glycation end-products and antibodies against carboxymethyl lysine (anti-CML) and carboxyethyl lysine (anti-CEL) in the sera of Graves' orbitopathy patients.