Open AccessRola błonowych receptorów melatoniny w zależnym od melatoniny uwalnianiu oksytocyny z układu podwzgórze-część nerwowa przysadki szczura — badania in vitro oraz in vivo
Author(s) -
Marlena Juszczak,
Monika Wolak,
Ewa Bojanowska,
Lucyna Piera,
Magdalena Roszczyk
Publication year - 2016
Publication title -
endokrynologia polska
Language(s) - Slovenian
Resource type - Journals
SCImago Journal Rank - 0.413
H-Index - 27
eISSN - 2299-8306
pISSN - 0423-104X
DOI - 10.5603/ep.a2016.0035
Subject(s) - luzindole , in vivo , receptor , melatonin , incubation , antagonist , receptor antagonist , in vitro , chemistry , explant culture , medicine , endocrinology , biology , biochemistry , microbiology and biotechnology
Melatonin exerts its biological role acting mainly via G protein-coupled membrane MT1 and MT2 receptors. To determine whether a response of oxytocinergic neurons to different concentrations of melatonin is mediated through membrane MT1 and/or MT2 receptors, the effect of melatonin receptors antagonists, i.e. luzindole (a non-selective antagonist of both MT1 and MT2 receptors) and 4-phenyl-2-propionamidotetralin (4-P-PDOT - a selective antagonist of MT2 receptor), on melatonin-dependent oxytocin (OT) secretion from the rat hypothalamo-neurohypophysial (H-N) system, has been studied both in vitro and in vivo.