Open AccessPolimorfizmy genu receptora witaminy D (TaqI oraz ApaI) oraz cyrkulacja osteokalcyny u pacjentów chorujących na cukrzycę typu 2 i osób zdrowych
Author(s) -
Edgar Alfonso Rivera-León,
Beatriz Palmeros-Sánchez,
Iris-Monserrat Llamas-Covarrubias,
Socorro Fernández,
Juan ArmendárizBorunda,
Mercedes González-Hita,
Blanca-Estela Bastidas-Ramirez,
Abraham ZepedaMoreno,
Sergio SánchezEnríquez
Publication year - 2015
Publication title -
endokrynologia polska
Language(s) - Polish
Resource type - Journals
SCImago Journal Rank - 0.413
H-Index - 27
eISSN - 2299-8306
pISSN - 0423-104X
DOI - 10.5603/ep.2015.0042
Subject(s) - taqi , medicine , calcitriol receptor , endocrinology , type 2 diabetes , genotype , overweight , vitamin d and neurology , diabetes mellitus , body mass index , biology , polymorphism (computer science) , genetics , gene
Vitamin D receptor (VDR) is encoded by the VDR gene. Several studies have supported that this gene is associated with diabetes. Heterodimer VDR/RXR functions as an enhancer of the BGLAP gene and increases the basal transcription rate of osteocalcin (OC) during osteoblast differentiation. OC is a regulator of glucose metabolism in mice. Moreover, OC level is decreased in patients with type 2 diabetes (T2D). Although inversely correlated with serum glucose insulin and glycated haemoglobin, it is unclear whether OC reduction is caused by diabetes or plays a role in the pathogenesis and/or progression of the disease. In this study we analysed the association between TaqI and ApaI VDR gene polymorphisms and OC serum concentration in T2D subjects.