Open AccessInfiltration of CD68+ cells correlates positively with matrix metalloproteinase 2 expression in the arteries used as aortocoronary bypass grafts. Possible clinical implications
Author(s) -
Bartłomiej Perek,
Katarzyna Kowalska,
Bartosz Kempisty,
Mariusz J. Nawrocki,
Michał Nowicki,
Mateusz Puślecki,
Danuta OstalskaNowicka,
Łukasz Szarpak,
Navid Ahmadi,
Agnieszka Malińska
Publication year - 2020
Publication title -
cardiology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.573
H-Index - 33
eISSN - 1897-5593
pISSN - 1898-018X
DOI - 10.5603/cj.a2019.0087
Subject(s) - medicine , cd68 , matrix metalloproteinase , cardiology , coronary arteries , coronary artery disease , artery , infiltration (hvac) , mmp9 , mmp2 , acute coronary syndrome , pathology , immunohistochemistry , myocardial infarction , downregulation and upregulation , biochemistry , chemistry , physics , cancer , gene , thermodynamics , metastasis
Late failure of arterial aortocoronary conduits may result from abnormal activity of cells found in the vessel wall, including macrophages. The purpose of this study was to assess if there are any associations between the number of macrophages and overexpression of matrix metalloproteinases (MMPs) in the wall of arterial grafts, as well as their clinical significance.