Open AccessThe effect of varenicline on Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in healthy smokers and nonsmokers
Author(s) -
Hasan Arı,
Selma Arı,
Selvi Coşar,
Nuran Celiloğlu,
İbrahim Aktaş,
Sencer Çamcı,
K. Doğanay,
Ahmet Tütüncü,
Mehmet Melek
Publication year - 2015
Publication title -
cardiology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.573
H-Index - 33
eISSN - 1897-5593
pISSN - 1898-018X
DOI - 10.5603/cj.a2015.0038
Subject(s) - qt interval , medicine , placebo , varenicline , crossover study , cardiology , supine position , anesthesia , heart rate , electrocardiography , nicotine , blood pressure , alternative medicine , pathology
Varenicline could affect the T wave and QT interval. The interval from the peak to the end of the electrocardiographic (ECG) T wave (Tp-e) may correspond to the transmural dispersion of repolarization, and increased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. In this study, we assessed the effects of varenicline on Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio.