Expression of tissue inhibitors of metalloproteinase 1 (TIMP-1) in gastric cancer tissue. | Zendy

A Kemonä | Zendy; Katarzyna Guzińska-Ustymowicz | Zendy; Mariusz Gryko | Zendy; Jolanta Czyżewska | Zendy; Magdalena Groblewska | Zendy; Marta ŁukaszewiczZając | Zendy; Barbara Mroczko | Zendy; Bogusław Kędra | Zendy; Maciej Szmitkowski | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Expression of tissue inhibitors of metalloproteinase 1 (TIMP-1) in gastric cancer tissue.

Author(s) -

A Kemonä,

Katarzyna Guzińska-Ustymowicz,

Mariusz Gryko,

Jolanta Czyżewska,

Magdalena Groblewska,

Marta ŁukaszewiczZając,

Barbara Mroczko,

Bogusław Kędra,

Maciej Szmitkowski

Publication year - 2010

Publication title -

doaj (doaj: directory of open access journals)

Language(s) - English

DOI - 10.5603/4325

Subject(s) - tissue inhibitor of metalloproteinase , metalloproteinase , cancer , matrix metalloproteinase , cancer research , pathology , medicine , biology

Degradation of extracellular matrix (ECM) is an essential step of invasion and metastasis of gastric cancer. The proteolysis of basement membranes depends on the balance between activities of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). The aim of the study was to assess the expression of TIMP-1 in gastric cancer (GC) and interstitial inflammatory infiltrate cells within GC tissue in relation to clinico-pathological features of tumor and to estimate the prognostic significance of TIMP-1 expression for patients' survival. The presence of TIMP-1 in 54 cases of gastric cancer samples was investigated by immunohistochemistry. The expression of TIMP-1 in cancer and interstitial inflammatory infiltrate cells was evaluated in semi-quantitative scale. The immunoreactivity of TIMP-1 in cancer and inflammatory cells was positive in 100% of cases and varied from weak to intense reaction. The intensity of TIMP-1 expression increased with more advanced tumor stages and in patients who died of cancer during 2-year observation. TIMP-1 expression in interstitial inflammatory infiltrate cells was the independent prognostic factor for patients' survival. The results suggest the role of TIMP-1 in gastric tumorigenesis, although this issue requires further investigtions

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research