Open AccessCaregiver willingness to give TPT to children living with drug-resistant TB patients
Author(s) -
Vanessa Rouzier,
Matthew Murrill,
S Kim,
Linda Naini,
Justin Shenje,
Erika Mitchell,
M Raesi,
Madeleine Lourens,
Alberto Mendoza,
Francesca Conradie,
Nishi Suryavanshi,
Michael D. Hughes,
Sarita Shah,
Gavin Churchyard,
Susan Swindells,
Anneke C. Hesseling,
Amita Gupta
Publication year - 2022
Publication title -
the international journal of tuberculosis and lung disease/the international journal of tuberculosis and lung disease. articles traduits en français ...
Language(s) - English
Resource type - Journals
eISSN - 1815-7920
pISSN - 1027-3719
DOI - 10.5588/ijtld.21.0760
Subject(s) - medicine , confidence interval , young adult , pediatrics , cross sectional study , tuberculosis , pathology
BACKGROUND Pediatric household contacts (HHCs) of patients with multidrug-resistant TB (MDR-TB) are at high risk of infection and active disease. Evidence of caregiver willingness to give MDR-TB preventive therapy (TPT) to children is limited. METHODS This was a cross-sectional study of HHCs of patients with MDR-TB to assess caregiver willingness to give TPT to children aged <13 years. RESULTS Of 743 adult and adolescent HHCs, 299 reported caring for children aged <13 years of age. The median caregiver age was 35 years (IQR 27-48); 75% were women. Among caregivers, 89% were willing to give children MDR TPT. In unadjusted analyses, increased willingness was associated with TB-related knowledge (OR 5.1, 95% CI 2.3-11.3), belief that one can die of MDR-TB (OR 5.2, 95% CI 1.2-23.4), concern for MDR-TB transmission to child (OR 4.5, 95% CI 1.6-12.4), confidence in properly taking TPT (OR 4.5, 95% CI 1.6-12.6), comfort telling family about TPT (OR 5.5, 95% CI 2.1-14.3), and willingness to take TPT oneself (OR 35.1, 95% CI 11.0-112.8). CONCLUSIONS A high percentage of caregivers living with MDR- or rifampicin-resistant TB patients were willing to give children a hypothetical MDR TPT. These results provide important evidence for the potential uptake of effective MDR TPT when implemented.