Open AccessRisk factors for TB in Australia and their association with delayed treatment completion
Author(s) -
N. J. Coorey,
L. Kensitt,
J. Davies,
E. Keller,
Meru Sheel,
Kudakwashe Chani,
Simone Barry,
Rowena Boyd,
Justin Denholm,
Krista Watts,
Greg J. Fox,
Christopher Lowbridge,
Rebecca Perera,
Justin Waring,
Ben J. Marais,
Kerri Viney
Publication year - 2022
Publication title -
the international journal of tuberculosis and lung disease/the international journal of tuberculosis and lung disease. articles traduits en français ...
Language(s) - English
Resource type - Journals
eISSN - 1815-7920
pISSN - 1027-3719
DOI - 10.5588/ijtld.21.0111
Subject(s) - medicine , logistic regression , incidence (geometry) , prospective cohort study , multivariate analysis , tuberculosis , cohort study , cohort , diabetes mellitus , physics , pathology , optics , endocrinology
BACKGROUND: Australia has a low incidence of TB and has committed to eliminating the disease. Identification of risk factors associated with TB is critical to achieving this goal. METHODS: We undertook a prospective cohort study involving persons receiving TB treatment in four Australian jurisdictions. Risk factors and their association with delayed treatment completion (treatment delayed by at least 1 month) were analysed using univariate analyses and multivariate logistic regression. RESULTS: Baseline surveys were completed for 402 persons with TB. Most (86.1%) were born overseas. Exposure to a person with TB was reported by 19.4%. Diabetes mellitus (10.2%), homelessness (9.2%), cigarette smoking (8.7%), excess alcohol consumption (6.0%) and mental illness (6.2%) were other common risk factors. At follow-up, 24.8% of patients had delayed treatment completion, which was associated with adverse events (34.1%, aOR 6.67, 95% CI 3.36-13.27), excess alcohol consumption (6.0%, aOR 21.94, 95% CI 6.03-79.85) and HIV co-infection (2.7%, aOR 8.10, 95% CI 1.16-56.60). CONCLUSIONS: We identified risk factors for TB and their association with delayed treatment completion, not all of which are routinely collected for surveillance purposes. Recognition of these risk factors should facilitate patient-centred care and assist Australia in reaching TB elimination.