Open AccessIntroduction of bedaquiline for the treatment of drug-resistant TB in the Philippines
Author(s) -
Mora Santiago,
Anna Marie Celina Garfin,
Vincent M. Balanag
Publication year - 2020
Publication title -
the international journal of tuberculosis and lung disease/the international journal of tuberculosis and lung disease. articles traduits en français ...
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.103
H-Index - 110
eISSN - 1815-7920
pISSN - 1027-3719
DOI - 10.5588/ijtld.20.0359
Subject(s) - bedaquiline , medicine , tuberculosis , pharmacovigilance , family medicine , agency (philosophy) , drug resistant tuberculosis , intensive care medicine , medical emergency , drug , pharmacology , pathology , mycobacterium tuberculosis , philosophy , epistemology
Treatment outcomes in patients with drug-resistant tuberculosis (DR-TB) remains unsatisfactory in the Philippines. To address this, we implemented the use of new anti-TB drugs and novel regimens. The Philippine National Tuberculosis Control Program (NTP) participated in the Bedaquiline (BDQ) Donation Program created by the US Agency for International Development and Janssen. Despite availability of donated medicine, there was a delay in the implementation of BDQ, both under operational research and programme conditions. The main challenges encountered were delayed approval by national and institutional ethics boards; limited experience of the NTP in the conduct of operational research into new drugs; and the lack of confidence of healthcare staff in the use of new and re-purposed anti-TB drugs. Technical assistance from partners and capacity building on clinical management of DR-TB and on pharmacovigilance among health workers were vital in overcoming these challenges. Over a 3-year period (from 2016–2018), 448 patients were initiated on BDQ-based regimens.