Open AccessThe effect of Madopar on absence-like seizures in WAG/Rij rats
Author(s) -
Ali Al-Kaleel,
Oytun Erbaş,
Hatice Aygün
Publication year - 2022
Publication title -
acta neurobiologiae experimentalis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 55
eISSN - 1689-0035
pISSN - 0065-1400
DOI - 10.55782/ane-2022-008
Subject(s) - open field , anesthesia , epilepsy , electrocorticography , medicine , psychology , neuroscience
The aim of this study was to investigate the effect of Madopar on the absence seizures and the anxiety‑like behavior (assessed usingthe open field test) in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Twenty‑eight male WAG/Rij rats were randomly divided into fourgroups: group I: control; group II: Madopar 5 mg/kg; group III: Madopar 50 mg/kg; group IV: Madopar 100 mg/kg. A tripolar electrodewas attached to all WAG/Rij rats. Electrocorticography (ECoG) recordings were made before and after Madopar (5, 50, and 100 mg/kg)injection for three hours. Anxiety‑related behavior was studied using the open field test for 5 min after the ECoG recordings. Madoparsignificantly reduced the number and duration of spike‑wave discharges (SWDs) when compared to the control group. The highest doseof Madopar (100 mg/kg) significantly reduced the duration of SWDs when compared to Madopar (5 mg/kg). All Madopar doses did notalter the duration of grooming, but the highest doses of Madopar significantly increased the number of squares crossed in the openfield test when compared to the control and Madopar (5 mg/kg) groups. These results revealed that Madopar reduced the absence‑likeseizures and the anxiety‑related behavior in WAG/Rij rats. This may emphasize the therapeutic properties of the Madopar/L‑dopa inabsence epilepsy.