Open AccessDrug delivery system for controlled release of empagliflozin from alginate-chitosannanocarrier system
Author(s) -
NASIM RAMAZANZADEH,
NOSRAT O MAHMOODI
Publication year - 2022
Publication title -
turkish journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.239
H-Index - 46
eISSN - 1303-6130
pISSN - 1300-0527
DOI - 10.55730/1300-0527.3370
Subject(s) - nanocarriers , thermogravimetric analysis , chemistry , chitosan , nuclear chemistry , fourier transform infrared spectroscopy , drug delivery , transmission electron microscopy , swelling , scanning electron microscope , infrared spectroscopy , controlled release , chemical engineering , nanotechnology , organic chemistry , materials science , engineering , composite material
A biocompatible nanocarrier system was prepared in this research through the reaction of calcium alginate (CA) with chitosan (CS). The structure of developed nanocarriers (CS-CA) was characterized by thermogravimetric analysis (TGA), Fourier transforms infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD) atomic force microscopy (AFM), and transmission electron microscopy (TEM). Swelling properties of CS-CA and CA, and their ability for loading and in vitro release of empagliflozin (EMP) were also investigated. The results showed the higher loading capacity of CS-CA compared to CA. For both nanocarriers, the drug release was higher at neutral pH (7.4 and 6.8) when compared to acidic pH (1.2). Despite the higher release of CA than CS-CA, the latter exhibited a favorable sustained drug release in all pH levels. As a result, CS-CA nanocarrier (EMP@CS-CANC) can be suggested as a new candidate for colon drug delivery of EMP.