Open AccessSynthesis and in vitro α-glucosidase and cholinesterases inhibitory actions of watersolublemetallophthalocyanines bearing ({6-[3-(diethylamino)phenoxy]hexyl}oxy groups
Author(s) -
Turgut Keleş,
ZEKERİYA BIYIKLIOĞLU,
Didem Akkaya,
Arzu Özel,
Burak Barut
Publication year - 2022
Publication title -
turkish journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.239
H-Index - 46
eISSN - 1303-6130
pISSN - 1300-0527
DOI - 10.55730/1300-0527.3368
Subject(s) - chemistry , inhibitory postsynaptic potential , acetylcholinesterase , in vitro , aché , ic50 , enzyme , cholinesterase , stereochemistry , non competitive inhibition , galantamine , medicinal chemistry , biochemistry , pharmacology , medicine , dementia , disease , pathology , neuroscience , biology , donepezil
In this paper, we have prepared peripherally tetra-({6-[3-(diethylamino)phenoxy]hexyl}oxy substituted cobalt(II), copper(II), manganese(III) phthalocyanines ( 3, 4, 5) and their water-soluble derivatives ( 3a, 4a, 5a) . Then, in vitro α-glucosidase and cholinesterases inhibitory actions of the water-soluble 3a, 4a, 5a were examined using spectrophotometric methods. 4a had the highest inhibitory effects among the tested compounds against α-glucosidase due to IC 50 values. 4a and 5a had 40 fold higher inhibitory effects than the positive control. For cholinesterases, the compounds showed significant inhibitory actions that of galantamine which was used as a positive control. According to the SI value, 3a inhibited acetylcholinesterase enzyme selectively. In kinetic studies, 4a was a mixed inhibitor for α-glucosidase, 3a was a competitive inhibitor for AChE, and 4a was a mixed inhibitor for BuChE. The therapeutic potential of these compounds has been demonstrated by in vitro studies, but these data should be supported by further studies.