Open AccessInfluence of aerobic exercise training on mice gut microbiota in Parkinson's disease
Author(s) -
TIANLUN FAN,
XIATING LI,
Xiang Zhang,
Jing Zhang,
LICHUN SUN,
JINGJING CHEN,
CHUAN FU
Publication year - 2022
Publication title -
turkish journal of biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.323
H-Index - 38
eISSN - 1303-6092
pISSN - 1300-0152
DOI - 10.55730/1300-0152.2617
Subject(s) - biology , lactobacillus gasseri , lactobacillus , firmicutes , microbiology and biotechnology , gut flora , dysbiosis , lactobacillaceae , bacteroidetes , actinobacteria , lactococcus , bacteria , lactococcus lactis , immunology , 16s ribosomal rna , genetics , lactic acid
Accumulating evidence shows that gut microbial dysbiosis may represent a risk factor for Parkinson's disease (PD). Exercise has a positive effect on microbiota in general. The effect of aerobic exercise training (AET) on the gut microbial environment in PD remains to be explored. Here, we performed the 16S rRNA gene sequencing on feces from sham operated-mice (sham), PD mice model, and mice receiving AET (AET). Results indicated that AET had no remarkable effect on species richness and bacterial diversity of PD mice. The relative abundance of the Bacteroidetes was reduced, while Firmicutes , Actinobacteria , Lactobacillaceae , Streptococcaceae , Lactobacillus , Streptococcus , Lactococcus , Lysinibacillus , Pelomonas , and Prevotellaceae_UCG-001 were increased in PD mice compared with those of sham operated-mice, whereas AET partly rescued their abundance. Additionally, the composition proportion of beneficial Lactobacillus_gasseri and u ncultured_Erysipelotrichales_bacterium significantly increased in AET mice compared to PD mice. Moreover, discriminative bacteria, such as Bacilli , Lactobacillales , Lactobacillaceae , Lactobacillus , and Lactococcus were identified as a specific taxon in AET mice. Here we provide evidence that AET can improve the gut microbiota of PD mice.