Open AccessIrisin relaxes rat thoracic aorta through inhibiting signaling pathways implicatingprotein kinase C
Author(s) -
Sadettin Demirel,
Serdar Şahintürk,
Naciye İşbil,
Fadıl Özyener
Publication year - 2022
Publication title -
turkish journal of medical sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.55730/1300-0144.5340
Subject(s) - medicine , phenylephrine , thoracic aorta , vascular smooth muscle , endocrinology , contraction (grammar) , vasodilation , aorta , protein kinase c , electrical impedance myography , contractility , vasoconstriction , bisindolylmaleimide , mesenteric arteries , kinase , artery , smooth muscle , biochemistry , chemistry , blood pressure
Irisin, a newly identified exercise-derived myokine, has been found involved in a peripheral vasodilator effect. However, little is known regarding the potential vascular activity of irisin, and the mechanisms underlying its effects on vascular smooth muscle have not been fully elucidated. This study was aimed to investigate the effects of irisin on vascular smooth muscle contractility in rat thoracic aorta, and the hypothesis that protein kinase C (PKC) may have a role in these effects.