Open AccessInterferon regulatory factor 5 gene variants rs2004640 and rs4728142 are associated with carotid intima media thickness but not with cardiovascular events in rheumatoid arthritis
Author(s) -
Rabia Agca,
A.M. van Sijl,
Saskia Vosslamber,
Alexandre E. Voskuyl,
C. L. Verweij,
M.T. Nurmohamed
Publication year - 2022
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/pf511x
Subject(s) - irf5 , medicine , rheumatoid arthritis , genotype , interferon regulatory factors , single nucleotide polymorphism , cohort , allele , arthritis , rheumatology , intima media thickness , immunology , rheumatoid factor , risk factor , gene , genetics , receptor , biology , carotid arteries , innate immune system
Rheumatoid arthritis (RA) is associated with cardiovascular (CV) morbidity and mortality. Interferon regulatory factor 5 (IRF5) gene polymorphisms rs2004640 and rs4728142 have been associated with autoimmune diseases, but also with atherosclerosis. Differences in IRF5 gene expression can lead to the production of different interferons and might play a role in the atherogenic process in RA.