Open AccessGalectin-3-binding protein is a novel predictor of venous thromboembolism in systemic lupus erythematosus
Author(s) -
Anne Peretz,
Niels Henrik Rasmussen,
Søren Jacobsen,
Christopher Sjöwall,
Christoffer Tandrup Nielsen
Publication year - 2021
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/ol0vqj
Subject(s) - medicine , hazard ratio , gastroenterology , leptin , thrombosis , adiponectin , proportional hazards model , confidence interval , insulin , insulin resistance , obesity
Venous (VTE) and arterial (AT) thrombosis in systemic lupus erythematosus (SLE) are poorly explained and difficult to predict. Leptin and tumour necrosis factor-like weak inducer of apoptosis (TWEAK) have been linked to subclinical atherosclerosis and galectin-3-binding protein (G3BP) to type I interferon activation and a pro-thrombotic environment. Thus, we explore serum G3BP, interferon gamma-induced protein 10 (IP-10), soluble CD163 (sCD163), TWEAK and leptin as predictors of VTE and AT, damage accrual, and all-cause mortality during follow-up in a Swedish SLE cohort.