The presence of both HLA-DRB1[*]04:01 and HLA-B[*]15:01 increases the susceptibility to cranial and extracranial giant cell arteritis | Zendy

D. Prieto-Peña | Zendy; Sara RemuzgoMartínez | Zendy; J. Gonzalo OcejoVinyals | Zendy; Belén AtienzaMateo | Zendy; Fernanda Genre | Zendy; Alejandro Muñoz-Jiménez | Zendy; F. Ortíz-Sanjuán | Zendy; Susana Romero-Yuste | Zendy; C. Moriano | Zendy; E. Galíndez-Agirregoikoa | Zendy; I. Calvo | Zendy; Norberto OrtegoCenteno | Zendy; Noelia Álvarez-Rivas | Zendy; José A. MirandaFilloy | Zendy; Irene Llorente | Zendy; Javier Garcı́a-Garcı́a | Zendy; Ricardo Blanco | Zendy; Oreste Gualillo | Zendy; Javier Martı́n | Zendy; Santos Castañeda | Zendy; Raquel LópezMejías | Zendy; Miguel Á. GonzálezGay | Zendy

Open Access

The presence of both HLA-DRB1[*]04:01 and HLA-B[*]15:01 increases the susceptibility to cranial and extracranial giant cell arteritis

Author(s) -

D. Prieto-Peña,

Sara RemuzgoMartínez,

J. Gonzalo OcejoVinyals,

Belén AtienzaMateo,

Fernanda Genre,

Alejandro Muñoz-Jiménez,

F. Ortíz-Sanjuán,

Susana Romero-Yuste,

C. Moriano,

E. Galíndez-Agirregoikoa,

I. Calvo,

Norberto OrtegoCenteno,

Noelia Álvarez-Rivas,

José A. MirandaFilloy,

Irene Llorente,

Javier Garcı́a-Garcı́a,

Ricardo Blanco,

Oreste Gualillo,

Javier Martı́n,

Santos Castañeda,

Raquel LópezMejías,

Miguel Á. GonzálezGay

Publication year - 2021

Publication title -

clinical and experimental rheumatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.184

H-Index - 95

eISSN - 1593-098X

pISSN - 0392-856X

DOI - 10.55563/clinexprheumatol/nn15lt

Subject(s) - medicine , giant cell arteritis , vasculitis , allele , human leukocyte antigen , pathology , biopsy , gastroenterology , immunology , biology , disease , antigen , genetics , gene

To determine if patients with the predominant extracranial large-vessel-vasculitis (LVV) pattern of giant cell arteritis (GCA) have a distinctive HLA-B association, different from that reported in biopsy-proven cranial GCA patients. In a further step we assessed if the combination of HLA-B and HLA-DRB1 alleles confers an increased risk for GCA susceptibility, either for the cranial and extracranial LVV phenotypes.

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