Open AccessThe presence of both HLA-DRB1[*]04:01 and HLA-B[*]15:01 increases the susceptibility to cranial and extracranial giant cell arteritis
Author(s) -
D. Prieto-Peña,
Sara RemuzgoMartínez,
Javier Gonzalo Ocejo-Vinyals,
Belén AtienzaMateo,
Fernanda Genre,
Alejandro Muñoz-Jiménez,
Francisco Ortiz-Sanjuán,
Susana Romero-Yuste,
C. Moriano,
Eva Galíndez-Agirregoikoa,
I. Calvo,
Norberto OrtegoCenteno,
Noelia Álvarez-Rivas,
José A. MirandaFilloy,
Irene Llorente,
Javier Garcı́a-Garcı́a,
R. Blanco,
Oreste Gualillo,
Javier Martín,
Santos Castañeda,
Raquel LópezMejías,
Miguel Á. González-Gay
Publication year - 2021
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/nn15lt
Subject(s) - medicine , giant cell arteritis , vasculitis , allele , human leukocyte antigen , pathology , biopsy , gastroenterology , immunology , biology , disease , antigen , genetics , gene
To determine if patients with the predominant extracranial large-vessel-vasculitis (LVV) pattern of giant cell arteritis (GCA) have a distinctive HLA-B association, different from that reported in biopsy-proven cranial GCA patients. In a further step we assessed if the combination of HLA-B and HLA-DRB1 alleles confers an increased risk for GCA susceptibility, either for the cranial and extracranial LVV phenotypes.