Open AccessAssociation of anti-RNA polymerase III antibody with silicone breast implants rupture in a multicentre series of Italian patients with systemic sclerosis
Author(s) -
Maria Grazia Lazzaroni,
Corrado Campochiaro,
Eugenia Bertoldo,
Giacomo De Luca,
Cristian Caimmi,
Anǵela Tincani,
Franco Franceschini,
Paolo Airò
Publication year - 2021
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/mg0paj
Subject(s) - medicine , autoantibody , breast cancer , connective tissue disease , cohort , antibody , systemic disease , cancer , pathogenesis , gastroenterology , autoimmune disease , immunopathology , immunology , disease
Systemic sclerosis (SSc) is a heterogeneous systemic autoimmune disease with distinct subsets identified by specific autoantibodies. Some environmental agents might play a role in SSc pathogenesis, including silicone breast implants (SBI). This association has been controversial in previous literature and only few studies reported the auto-antibody status in these SSc women. The objective of this study was to evaluate the association of SBI with SSc in a large cohort of Italian patients, classified according to their SSc-related autoantibodies and to their history of breast cancer.