Open AccessPathogenesis of rheumatoid arthritis: one year in review 2022
Author(s) -
Fiorella Petrelli,
Francesco Mariani,
Alessia Alunno,
Ilaria Puxeddu
Publication year - 2022
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/l9lyen
Subject(s) - pathogenesis , medicine , rheumatoid arthritis , immunology , immune system , disease , inflammation , arthritis , genetic predisposition , innate immune system , acquired immune system , bioinformatics , pathology , biology
The mechanisms underlying the pathogenesis of rheumatoid arthritis (RA) involve different components of the immune system. In subjects with genetic predisposition to develop RA, a tight interaction between cells and mediators of the innate and adaptive immune system leads to the amplification and perpetuation of inflammation and tissue remodelling. The research carried out in the last year in the field of RA has improved the current knowledge on the pathogenesis of the disease, and is potentially useful to develop new therapeutic approaches. Thus, in this review we provide an overview on the new insights into RA pathogenesis, resulting from a literature search of the data published in the last year.