Open AccessAssociation between serum amyloid A1 genotype and age of onset restricts to M694 homozygote familial Mediterranean fever patients in Armenia
Author(s) -
Gernot Kriegshäuser,
Hasmik Hayrapetyan,
Stepan Atoyan,
Christian Oberkanins,
Tamara Sarkisian
Publication year - 2021
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/hvktbk
Subject(s) - mefv , familial mediterranean fever , medicine , genotype , amyloidosis , compound heterozygosity , gastroenterology , allele , disease , pathology , gene mutation , genetics , mutation , biology , gene
Familial Mediterranean fever (FMF) is an autosomal-recessive, inflammatory disorder characterised by short, recurrent attacks of fever, accompanied by pain in the abdomen, chest, or joints and complications of amyloidosis. Recently, we observed a significant association between the serum amyloid A1 (SAA1) β/β genotype and a delayed disease onset in 386 M694V homozygous FMF patients. This follow-up study was conducted to additionally analyse MEFV genotypes other than M694V/M694V for a possible influence of the SAA1 genotype on the age of disease onset.