Open AccessThrombin generation potential is enhanced in systemic sclerosis: impact of selected endothelial biomarkers
Author(s) -
Piotr Kuszmiersz,
Renata PacholczakMadej,
Angelika Siwiec,
Magdalena CelińskaLöwenhoff,
Teresa Iwaniec,
Joanna Kosałka-Węgiel,
Lech Zaręba,
Stanisława BazanSocha,
Jerzy Dropiñski
Publication year - 2021
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/d03dnc
Subject(s) - thrombomodulin , medicine , thrombin , immunology , endothelial activation , protein c , endothelium , platelet
Systemic sclerosis (SSc) is a rare immune-mediated heterogenous entity characterised by excessive tissue fibrosis and vascular injury. Recently, increased risk of thromboembolic events has been documented in that disease. Our aim was to investigate prothrombotic plasma properties together with selected laboratory biomarkers of endothelial injury in SSc.