Open AccessSubphenotypes of ANCA-associated vasculitis identified by latent class analysis
Author(s) -
Krzysztof Wójcik,
Grzegorz Biedroń,
Katarzyna Wawrzycka-Adamczyk,
Stanisława BazanSocha,
Adam Ćmiel,
Zbigniew Zdrojewski,
Anna Masiak,
Zenobia Czuszyńska,
Maria Majdan,
Radosław Jeleniewicz,
Marian Klinger,
Magdalena Krajewska,
Mariusz Kusztal,
Marek Brzosko,
Iwona Brzosko,
Alicja DębskaŚlizień,
Hanna Storoniak,
Barbara BułłoPiontecka,
Witold Tłustochowicz,
Joanna Kur-Zalewska,
Małgorzata Wisłowska,
Marta Madej,
Anna Hawrot-Kawecka,
Piotr Głuszko,
Małgorzata Stasiek,
Eugeniusz J. Kucharz,
Jacek Musiał
Publication year - 2021
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/d01o72
Subject(s) - medicine , microscopic polyangiitis , granulomatosis with polyangiitis , latent class model , vasculitis , disease , serology , cohort , etiology , immunology , antibody , statistics , mathematics
ANCA-associated vasculitides (AAV) are a heterogeneous group of rare diseases with unknown aetiology and the clinical spectrum ranging from life-threatening systemic disease, through single organ involvement to minor isolated skin changes. Thus, there is an unmet need for phenotype identification, especially among patients with granulomatosis with polyangiitis (GPA). Patients with microscopic polyangiitis (MPA) seem to be clinically much more uniform. Recently, three subcategories of AAV have been proposed and described as non-severe AAV, severe PR3-AAV, and severe MPO-AAV.